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Unlike Botox, it works gradually over weeks of consistent twice-daily application

10.1038/s41419-021-04227-0 24 KuboH.AsaiK.KojimaK.SugitaniA.KyomotoY.OkamotoA.et al (2019)

Deficiency leads to nerve damage (neuropathy), which presents as numbness, tingling, or weakness

The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling