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This diagnostic step is crucial for determining the cause of the deficiency and creating an appropriate treatment plan

Poor lipid metabolism is often associated with conditions like insulin resistance[8], which can lead to increased fat storage and difficulty maintaining a healthy weight

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However, the certain evidence whether the inhibition of ADO-mediated signaling pathway has a direct impact on anti-MM activities of CD38 mAbs is still confusing because of the technical challenges of direct measurement of ADO level in patients [84, 85]