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Strategies for accelerating glucose depletion in tumor cells mainly include the delivery of glucose oxidase (GOx), co-delivery of GOx and oxygen, co-delivery of GOx and oxygen-generating compounds, and photodynamic/photothermal-driven glucose depletion

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for both the ER-targeting sequence that corresponds to the N-terminal (17 amino acids of mouse calreticulin) and ER-retention signal, KDEL was fused to the N-terminus or C-terminus of scFv-A36, respectively 61