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Xiu Y, Kong XR, Zhang L, Qiu X, Chao FL, Peng C et al

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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

In terms of metabolic regulation, there would be a metabolic paradigm shift, presenting with remarkable increase in glycolysis process and lactate production in tumor cells, when DHRS7 expression was reduced, undoubtedly providing sufficient energy supply and biosynthesis material basis for the crazy proliferation and tenacious survival of cancer cells [25]