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Generating evidence from expanded access use of rare disease medicines: challenges and recommendations

Medeiros DM, Jiang Y, Klaahsen D, Lin D

The fasted state is criticalinsulin suppresses NNMT activity, so dosing during fed states reduces 5-Amino-1MQ's efficacy

The BDNF valine 68 to methionine polymorphism increases compulsive alcohol drinking in mice that is reversed by tropomyosin receptor kinase B activation

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