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Sequential therapy is well established in oncogene-driven cancers, particularly EGFR-mutant nonsmall cell lung cancer, where first or second-generation EGFR tyrosine kinase inhibitors are followed by Osimertinib upon emergence of T790M-mediated resistance (181183)

[52] in a randomized, double-blind, placebo-controlled clinical trial demonstrated that acute hyperglycemia significantly impaired endothelium-dependent vasodilation in healthy subjects, whereas treatment with the RBX effectively preserved vascular responses, thereby preventing hyperglycemia-induced endothelial dysfunction

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Female comprised 33.8% in HC and 34% in UC