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100 Inhibiting the receptor for macrophage M-CSF using PLX3397 successfully decreased macrophage density and promoted tumour regression in a fraction of the mice tested, but only once pNFs had been established

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Nat Rev Mol Cell Biol (2016) 17(11):691702

But addressing the immune imbalance is critical to STOPPING FURTHER DESTRUCTION of thyroid tissue, and in cases where Hashimotos is caught early enough, it may prevent hypothyroidism from developing in the first place