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HGH Fragment 176-191 Research# The fragment has been studied primarily as AOD-9604 (an analog with improved stability): Preclinical models : Demonstrated selective fat loss in obese rodent models with 2-3 fold increases in fat oxidation, reduction in adiposity, and glycemic neutrality Phase 2 clinical trial : AOD-9604 was tested in obese adults but did not demonstrate statistically significant weight loss compared to placebo in the primary endpoint analysis Mechanism studies : In vitro data confirm ACC inhibition, HSL activation, and absence of GHR binding Oral formulation : Some studies have explored oral delivery of AOD-9604, representing a departure from the injectable route typical of peptide therapeutics The clinical evidence base is significantly thinner than that of full-length GH, and no regulatory approvals have been granted for the injectable peptide fragment in any major market

Because some HOPDs may only elect to report this eCQM for some reporting periods, we are unable to assume that 80 percent of HOPDs will not report this measure in any reporting period

All parties involved in the case will then receive a copy of this affidavit

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