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We further proposed that if a manufacturer submits a complete and timely extension request, and CMS determines that the information submitted warrants an extension of the rebate reduction, the total rebate amount would be reduced by 75 percent for a second consecutive applicable period for that manufacturer's generic Part D rebatable drug in accordance with 428.303(b)(2)

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Results: Analysis of human CCA cells and primary tumours revealed increased expression and activity of the SUMOylation machinery, correlating with unfavourable clinical outcomes