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Deficient glutamate clearance drives neuronal damage in neurotoxic disorders such as WernickeKorsakoff encephalopathy or hepatic encephalopathy 137,138,139 , whereas diminished K + buffering together with insufficient glutamate clearance leads to spreading depression, migraine and epilepsy 140,141,142

These cytokines can promote tissue healing and regeneration but can also exacerbate inflammation and fibrosis, thereby contributing to the progression of POP and UI in preclinical studies

5 "We're very pleased to be partnering with Jazz to raise awareness of idiopathic hypersomnia