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Free Radic Biol Med 49:16171628 Cooper AJL, Pulsinelli WA, Duffy TE (1980) Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain

doi: 10.1155/2007/31867 17 SramekJNemcova-FurstovaVKovarJ

Vitamin C assists in this recycling process, which is why the two are often delivered together

Non-enzymatic antioxidants function through several mechanisms: Direct radical scavenging : Neutralizing free radicals by donating electrons or hydrogen atoms Metal chelation : Binding transition metals like iron and copper that catalyze free radical generation Quenching : Absorbing and dissipating the energy from reactive oxygen species Chain-breaking : Interrupting chain reactions of lipid peroxidation Regeneration : Recycling other antioxidants back to their active forms Unlike enzymatic antioxidants that catalyze multiple reactions without changing, non-enzymatic antioxidants become oxidized during their protective action and require regeneration