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For some researchers, the additional weight loss from higher doses is not worth the increased side effect burden, and a dose between 1.0 and 1.7 mg represents their personal optimal balance

PMID: 33278218 Bruni O, Breda M, Nobili L, Fietze I, Capdevila ORS, Gronfier C (2024) European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children

(1/) pnas.org/doi/abs/10.107 Females show higher mtROS levels and insufficient antioxidant levels, while males show mitochondrial lipid oxidative damage