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In the following study by Zhao et al., it has been identified that HK2 can be degraded by tripartite motif containing 36 (TRIM36) through ubiquitination, which leads to the reduction of GPX4 and facilitates ferroptosis in tumor cells [21]

They observed that these mice exhibit elevated iron and 4-HNE levels, increased erythrocyte phagocytosis by plaque macrophages, and enhanced macrophage ferroptosis, leading to greater necrosis in atherosclerotic plaques

Conception and Evaluation of Fluorescent Phosphine-Gold Complexes: From Synthesis to in vivo Investigations

Additionally, YCHD did not cause spleen weight loss or hepatocyte degeneration in mice