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2.3 Metabolic reprogramming characteristics 2.3.1 Mitochondrial fragmentation and inhibition of oxidative phosphorylation Within exhausted T cells, the morphological and functional abnormalities of mitochondria resemble a malfunctioning energy factory, profoundly reflecting their metabolic reprogramming characteristics

Annals of Internal Medicine, 115(12), 956-965

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A distinctive pathological feature of ALS is the mislocalization and aggregation of phosphorylated TDP-43 (pTDP-43), a nuclear RNA-binding protein encoded by TARDBP