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Fourth, advanced biomimetic functionalization approaches, such as cell membrane coating (using red blood cell, cancer cell, or bacterial membranes), could be employed to endow COF nanoparticles with prolonged blood circulation, enhanced active targeting, and immune evasion capabilities, thereby optimizing their pharmacokinetic profiles

This postmortem study helped confirm other studies indicating the importance of all three carotenoids in maintaining the structural integrity of the macula (Krinsky 2003)