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Mtb can also incorporate propionyl-CoA into its cell wall, including the virulence-associated lipids phthiocerol dimycocerosates (PDIM) and the trehalose ester family (sulfolipid-1 (SL-1), diacyltrehalose, triacyltrehalose, and polyacyltrehalose), which are synthesised from malonyl-CoA (produced from acetyl CoA) and methylmalonyl-CoA (produced from propionyl-CoA) (Lee et al, 2013)

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635 A double-blind, randomized, placebo-controlled trial of LX-9211 for pain relief and safety in DPN initially found that LX-9211 improved PDPN