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Patients with cardiovascular disease, chronic kidney disease, or other obesity-related complications may benefit from extended treatment, though cardiovascular and renal outcome trials with tirzepatide are still ongoing, and definitive risk reduction benefits remain under investigation

J Cell Biol 118: 309320

Inter-organ signaling in plants: Regulation of ATP sulfurylase and sulfate transporter genes expression in roots mediated by phloem-translocated compound