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*.Birkholz A, Kopecky DJ, Volak LP, Bartberger MD, Chen Y, Tegley CM, Arvedson T, McCarter JD, Fotsch C, Cee VJ: Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2

B vitamins generally have a low risk of interacting with medications, though some supplements can cause interference

If needles aren't your thing, B12 supplements are also available in capsule, tablet, and liquid forms, which can often be purchased over-the-counter (via Medical News Today)

The argument can be made that large scientific studies are expensive, and no company is going to spend the money to conduct these studies on natural supplements for which a patent cannot be obtained