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10.1016/j.jep.2023.116537 J Ethnopharmacol

The hypothesis is, if this IV glutathione response is observed, then it demonstrates severe glutathione precursor RND

Parallel modifications in chemokines (particularly CCL2/MCP-1, CXCL10/IP-10, and CX3CL1) suggest greater leukocyte recruitment and endothelial activation, which have been associated to increased BBB permeability and CNS immune cell trafficking [91]

The use of silymarin alone or in combination with retinol can reduce the CYP26B1 protein signal, which may indirectly promote the anti-inflammatory effect and improve the extracellular matrix (ECM) by regulating the clearance of retinol through CYP26B1 ( Figure 5 )