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In fact, the multifunctional molecules released by the sensory system may exacerbate certain diseases

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Pneumonia Bacterial pneumonia, such as that caused by Pseudomonas aeruginosa , can impair synaptic plasticity in hippocampal neurons via Tau-dependent mechanisms, leading to cognitive deficits [3, 25, 26]

Although lower thiamine deficiency also affects -KGDH activity, which is essential to maintain the levels of Glu, Asp, and GABA, its activity seems to be less affected than PDC, thus providing an operational Krebs cycle albeit at a lower efficiency