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Adv Clin Exp Med (2017) 26(9):14315

This contrasts with the aforementioned direct protective effects targeting the brain or spinal cord in neurological diseases, yet shares a consistent mechanistic core: upregulating Nrf2 at central nervous system sites can significantly influence the pathological progression of systemic or multi-system diseases

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In this respect, it should be noted that many of these diet-related metabolites were microbial-transformed compounds (e.g., phenolic acids, valerolactones)