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FIGURE 1 Next to this evidence, in our laboratory it has been demonstrated that GSH depletion modulates the peroxisome proliferator-activated receptor gamma, co-activator 1 alpha (PGC-1) expression and its downstream metabolic pathway in neuronal and skeletal muscle cells ( Figure 1 )

It was also found that 968 was capable of reversing adriamycin resistance in MCF-7/ADR, a drug-resistant cell line of BC, in a time- and drug-concentration-dependent manner [145]

It has been reported that methionine can be easily oxidized to methionine sulfoxide by some oxidants such as oxygen, ozone, hydrogen peroxide, and superoxide (Levine et al., 2000)