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However, effector molecules involved in an E2-independent action of Er ( ESR1 ) activation involved in cell proliferation in hyperplastic ovary still need further investigation

Lancet 379 , 21622172 (2012)

In addition, baicalein (BAE) and DOX were separately loaded into cationic solid lipid nanoparticles to form BAE-SLN and DOX-SLN, where BAE-SLN was modified with aminoethyl aniline amide (AEAA) to form AEAA-BAE-SLN (ABS) and DOX-SLN was modified with folic acid (FA) to form FA-DOX-SLN (FDS), and both were further encapsulated in carboxymethyl chitosan (CMCS) to form the nanocapsule NPC-ABS/FDS which can enhance CD8 + T and CD4 + T cells infiltration, reduce Tregs, and significantly inhibit tumor growth (165)