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In addition to solid tumors, a Phase I/II clinical trial of SSZ for ferroptosis-dependent induction treatment for acute myeloid leukemia (AML) is recruiting subjects (NCT05580861)

These findings suggest that Rhizoma Gastrodiae has potential applications in the treatment of osteoporosis, warranting further exploration ( 4.3.2 Improvement of immunity Rhizoma Gastrodiae polysaccharide GDP has been shown to induce NO release in RAW264.7 cells, thereby activating immune cells and significantly enhancing the phagocytic activity of RAW264.7 macrophages ( 4.3.3 Anti-tumour effect Studies have demonstrated that Rhizoma Gastrodiae exhibits antitumor activity, with underlying mechanisms involving multiple aspects

Benoist 2011, PMID 21719467, which studied Nle1-AngIV analogs rather than Dihexa itself)

doi: 10.1016/j.cmet.2016.07.010 90 PuchalskaPCrawfordPA