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An "RNA interference agent" as used herein is defined as any agent that interferes with or inhibits the expression of a target biomarker gene by RNA interference (RNAi)

Am J Physiol Heart Circ Phisiol (2005) 289(1):H99107

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Radiation-induced DNA damage is sensed by the kinases ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related protein (ATR), which activate downstream proteins to initiate the DNA damage response (reviewed in Maier et al., 2016)