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In a large prospective cohort of 14,542 participants, chronic antibiotic use in midlife was associated with cognitive impairment later in life, such that antibiotic use was associated with an additional three years of aging, compared to those with no antibiotic exposure (407)

and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp 2060-2080

7 Abnormalities in biochemical tests such as hyperbilirubinemia, hypoalbuminemia, decreased blood urea nitrogen (BUN), hypoglycemia, and increased SBA indicate hepatic dysfunction and a more advanced stage of disease