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G protein-coupled receptor-G protein interactions: a single-molecule perspective

Furthermore, targeted ophthalmic trials utilizing T4-based eye drops (such as the RGN-259 formulation) have demonstrated safety and clinical efficacy in treating severe dry eye conditions, bacterial corneal infections, and physical corneal wounds

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This study also demonstrated that treatment with rhDKK1 negated Wnt-mediated activation of -catenin, thereby inducing apoptosis in outer root sheath keratinocytes via induction of pro-apoptotic protein Bax [41]