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Health Care 16 , 473482 (2004)

Targeting VEGF/VEGFR to enhance effector T-cell function by antiangiogenic agents: VEGF is a crucial link between tumor growth and the immune response directed at that tumor since it promotes both neoangiogenesis and immunosuppression [78]

This timing is not arbitrary

The implication of these findings is substantial, as it gives the chance to tackle the transition from autoimmunity to inflammation by restoring intestinal barrier function and thereby preventing the onset of RA