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& Maggi, M

The selectivity operates at multiple levels: structural, receptor-based, and tissue-specific

The KEGG enrichment analysis also revealed that these groups of genes were enriched in various metabolism pathways such as cytochrome P450-related metabolism process, retinol metabolism, and neuroactive-ligand receptor interaction (Fig S4A

This cellular energy crisis directly manifests as the profound physical fatigue, "brain fog," and post-exertional malaise (PEM) that patients experience