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At the higher recommended doses, there is a proportional increase in the concentrations of free and bound racemate

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Results Vacuolar deacidification activates autophagy flux in nutrient-rich medium Dysfunctional V-ATPase and lysosomal/vacuolar deacidification are thought to impair autophagy activity by hindering the degradative efficiency of lysosomal/vacuolar hydrolytic enzymes 16,23