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Both activation of the G-protein-coupled receptor GPR35 (Berlinguer-Palmini et al., The concepts of acute and chronic glutamate toxicity The term excitotoxicity was first used by Olney (1986) to describe the ability of L-glu, as well as structurally related amino acids, to kill nerve cells, a process that has been proposed to take place not only in acute but also chronic diseases of the central nervous system (for reviews Choi, 1990)

Microglia, the brains resident immune cells, become activated and release pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 (50, 51)

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The transcription factor NF-B/p65, the expression of cellular inflammatory factors (IL-1, IL-6, IL-11, and TNF-), is regulated by Akana