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The combo is a tool for the plateau, not a mandatory entry point

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As stated for the Hospital IQR Program, the case threshold exemption means that for each quality measure where the minimum number of patients that meet the patient population denominator criteria for the relevant reporting period is not met, REHs could declare a case threshold exemption. Specifically, for the REHQR Program, we proposed that beginning with the CY 2027 reporting period/CY 2029 program determination, if an REH's EHR system is certified to report an eCQM and the REH has 5 or fewer outpatient encounters or discharges per quarter or 20 or fewer outpatient encounters or discharges per year (Medicare and non-Medicare combined), as defined by an eCQM's denominator population, that REH would be exempt from reporting on that eCQM

Intervention studies employing dopaminergic neuron-targeted PGC-1 overexpression via adeno-associated viral vectors reveal enhanced redox homeostasis in striatal neurons and marked attenuation of programmed dopaminergic cell death, establishing this transcriptional coactivators neuroprotective capacity in PD pathophysiology (Wang et al., 2019c)