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This convergence of intracellular signaling architecture despite divergent extracellular binding mechanisms is a key insight from the orforglipron structural studies

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Brown EE, DeWeerd AJ, Ildefonso CJ, Lewin AS, Ash JD (2019) Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

Those ligand-target bindings would include benzodiazepine, opioid, (1)- and (2)-adrenergic, serotonergic and cholinergic receptors 85 and, notably, the fascinating issue of the anti-nociceptive role of melatonin seems to be mediated by MT1 and MT2 receptors themselves 86 , 87,88