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Alternative hypotheses (notably, the BBB hypothesis) in the 19th century have already been used to explain some phenotypes associated with epilepsy (63, 64)

For HPLC methods and MS parameters please refer to supplementary methods 53

Besides, polyphenols also influence other mechanisms which tend towards improvement of muscle performance, for instance mitochondrial biogenesis comprises of two methods, either stimulating stress-related cell signaling pathways, increasing expression of genes encoding cytoprotective proteins such as nuclear respiratory factor 2 (NRF2) where variants of the NRF2 gene have been associated with endurance performance, or modulating muscle function and mitochondrial biogenesis by upstream regulation of sirtuins (SIRT1) and peroxisome proliferator-activated receptor coactivator (PGC-1) activity (Somerville et al

therefore, inhibiting this inflammation, induced by MSU crystals, may present a therapeutic approach to managing HUA and related complications (65)