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[DOI] [PubMed] [Google Scholar] 29.Garza-Lombo C, Gonsebatt ME

In vitro models using THP-1-derived macrophages and HUVECs exposed to ox-LDL-conditioned media show that KPs decrease VCAM-1 and ICAM-1 expression by up to 40%, indicating potent attenuation of endothelial activation (Herrero-Fernandez et al., 2019)

Lurette et al., 2023

The US FDA has studied the data of 254 medicines in the LTKB-BD (Liver Toxicity Knowledge base Benchmark Dataset) and found that regardless of the administered dose, drugs metabolized by cytochrome P450 (CYP) enzymes CYP1A2, CYP2C8/CYP2C9 and CYP3A5 were more likely to cause DILI (Yu et al., 2014)