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Rheinstdter et al., 2004

Are patients who have metabolic syndrome without diabetes at risk for developing chronic kidney disease

This impairment often involves downregulation of key tight junction proteins (e.g., occludin, claudins, zonula occludens-1 [ZO-1]) and mucin components at both RNA and protein levels, which disrupts epithelial integrity and facilitates fungal translocation 19,109