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Alterations of the types of gut microbiota can dysregulate metabolic processes, leading to several diseases [18, 19]

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Most of the studies focused on acetate, propionate, and butyrate, however, the anti-tumor effect of valerate, specifically in NSCLC is poorly understood

This is achieved by stimulating the activity of immune cells, such as M1 macrophages and CD8+ T lymphocytes, and by promoting the secretion of pro-inflammatory cytokines, including interferon-gamma