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DOI: 10.1038/s41467-017-01114-1 Therapeutic peptide formulation stability - Review of pH, ionic strength, aggregation, and other formulation variables that affect peptide stability

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Realizing this potential requires addressing critical gaps: although preclinical studies highlight innovative mechanisms (e.g., multimodal therapies and stimuli-responsive release), robust clinical validation remains scarce, necessitating phase I/II trials to confirm efficacy and safety

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