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11 , R180 (2009)

Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti-and pro-angiogenic therapies

That is a meaningful preclinical signal but it is a single research groups model, in one species, without the independent multi-lab replication that would be needed before any human inference

Those who have had gastric bypass or other intestinal surgeries These surgeries often cause permanent or temporary GI issues and malabsorption syndromes (2)