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Elevated levels of MNAM were detected in the urine (Li et al., 2018) and serum (Kannt et al., 2015) of individuals with T2D, suggesting an increase in NNMT activity during T2D development

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Of note, the relative abundance of the Parasutterella genus, which was significantly enriched in both the vehicle- and 5A-1MQ-treated animals transitioned from WD to LD compared to both the WD and LD control groups, was observed to be significantly correlated (either positively or negatively) with 30 EWAT metabolites, both with and without outliers included