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58 The murine constant regions of MOv19 (2a, ) were replaced with human CL () and CH (1) to generate the chimeric antibody ChiMOv19, which exhibited similar or superior ADCC activity than its murine counterpart

Example: The modification of a single base pair in the gene encoding the beta globin chain, which causes the amino acid residue glutamate to change to valine, is a typical case of a point mutation

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