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As a result of these changes in histone acetylation and methylation, chromatin accessibility and the transcription of genes regulating cell proliferation and apoptosis are altered

Since EXOs cannot reproduce and are not mutagenic, they are a safer option for biological carriers than viral vectors or cell therapy

doi: 10.1097/HJH.0b013e3282fd9936 113

We validated the expression of Tsc22d3 room air murine lung and showed expression in Adgre1 + lung macrophages and Siglecf + alveolar macrophages ( Supplemental Figure 5D-E )