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The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer

Nevertheless, if drugs inhibit ThDP-dependent enzymes, as, e.g., omeprazole does (157), direct exposure of the gastrointestinal system to oral drugs may increase its vulnerability compared to other tissues

Under the ROS stimulation, the thin-sophisticated moiety (-SH) of cysteine residues is oxidized to form reversible intramolecular disulfide bonds (R-S-S-R) and sulfinyl groups (R-SOH), or irreversible sulfinic acids (R-SO 2 H) and sulfonic acids (R-SO 3 H) ( As we mentioned earlier, GPX7 does not contain domains bound to GSH, so it cannot participate in redox reactions with GSH as a substrate like other GPX family members