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Burbridge MF, Bossard CJ, Saunier C, Fejes I, Bruno A, Leonce S, et al

Because its activity centers on angiogenesis modulation, study designs in oncology-adjacent contexts typically account for this mechanism

Notably, ECs display considerably reduced levels of intercellular adhesion molecules (ICAMs) in comparison to ECs in peripheral organs, thereby imposing stringent limitations on immune cell ingress into the brain tissue [34, 35]