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Additionally, a study on healthcare workers investigated CLOCK, BMAL1, and PER1 polymorphisms in relation to hypertension, finding that the CLOCK rs1801260 GG and BMAL1 rs11022775 TT genotypes were associated with a reduced risk of hypertension, whereas PER1 rs2735611 showed no significant association, highlighting how circadian gene variants may influence cardiovascular outcomes in NS workers 218

Aoyama 2021) (Fig

c-KIT phosphorylation directly activates p38 mitogen-activated protein kinase (MAPK), a member of the MAP kinase family, which in turn phosphorylates CREB and subsequently activates MITF to promote TYR transcription (34)

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