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Its prevalence has risen dramatically since 1980, when it was a perplexing and sporadically-observed disease as first reported by Ludwig and colleagues (1), to a current estimated 25% global prevalence.(2) NAFLD represents the leading cause of chronic liver disease and is the second leading indication for liver transplantation in the United States.(3) Its rise parallels the obesity epidemic and is attributed to the concomitant rise in the prevalence of type 2 diabetes and metabolic syndrome

p38 MAPK has been implicated in a number of cellular processes, including the cell cycle, apoptosis, differentiation, neoplasm metastasis, angiogenesis and vasculogenesis (63)

Kumar A, Kumar A, Cabral-Pinto M et al (2020b) Lead toxicity: health hazards, influence on food chain, and sustainable remediation approaches