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under normal conditions, BDNF binds to TrkB receptors to activate pathways such as ERK and Akt, activating the mammalian target of rapamycin complex 1 (mTORC1), which drives synaptic protein synthesis, promoting dendritic spine and synapse formation, and maintaining synaptic structures (118)

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In summary, miRNAs influence targeted therapy sensitivity by affecting signaling pathways, intracellular processes, and receptor regulation, highlighting their crucial role in tumor drug resistance and offering potential targets for new therapies

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