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AF9, a paralog of ENL that is also bound by this chemical series 30 , was too lowly expressed in MV4;11 cells to evaluate degradation by proteomics, but an immunoblot analysis of endogenously expressed AF9 suggests it can also be degraded by dHTC1 (Extended Data Fig

The most commonly reported adverse events in the Phase 2 trial were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class

Cisplatin, for example, is known to induce in ovarian cancer cells NF-B [63], a transcription factor that controls the production of major proinflammatory agents, such as tumor necrosis factor (TNF) and IL-1, IL-6, IL-8 [64]

Phytochem Rev 22 , 16371661 (2023)