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When the circulating lymphocytes no longer have to expend massive amounts of energy synthesizing their own emergency glutathione to survive, they can return to their normal, regulatory functions

key MAPK pathways, such as ERK1/2, JNK, and p38, control essential cellular processes like proliferation, differentiation, apoptosis, and stress responses

2.2 Mechanical microenvironment 2.2.1 Tumor-associated fibroblasts Fibroblasts are resting in normal tissues, but they can be activated by growth factors secreted by tumor cells and differentiate into myofibroblasts