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365,366 In mouse hypoxic lung tissue and PASMCs, upregulated Circ-Ntrk2 activates TGF- expression by targeting miR-296-5p, which subsequently upregulates p38 and finally promotes PASMC proliferation and pulmonary vascular remodeling

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Anglemyer et al., Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials, Cochrane Database of Systematic Reviews, doi:10.1002/14651858.MR000034.pub2